10.1021/acs.joc.5b00977.s002 Shinya Higashimae Shinya Higashimae Taichi Tamai Taichi Tamai Akihiro Nomoto Akihiro Nomoto Akiya Ogawa Akiya Ogawa Selective Thiolative Lactonization of Internal Alkynes Bearing a Hydroxyl Group with Carbon Monoxide and Organic Disulfides Catalyzed by Transition-Metal Complexes American Chemical Society 2015 Organic Disulfides Catalyzed alkyne Pd homopropargyl alcohol derivatives disulfide hydroxyl group thiolative lactonization hydroxy group dicobalt octacarbonyl Selective Thiolative Lactonization Internal Alkynes Bearing palladium catalyst 2015-07-17 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Selective_Thiolative_Lactonization_of_Internal_Alkynes_Bearing_a_Hydroxyl_Group_with_Carbon_Monoxide_and_Organic_Disulfides_Catalyzed_by_Transition_Metal_Complexes/2148847 Although many transition-metal catalysts are ineffective for the addition and carbonylative addition of organic disulfides to internal alkynes, dicobalt octacarbonyl and palladium complexes such as Pd­(PPh<sub>3</sub>)<sub>4</sub> and Pd­(OAc)<sub>2</sub> were found to exhibit excellent catalytic activity for the thiolative lactonization of internal alkynes bearing a hydroxyl group. In the presence of the cobalt or palladium catalyst, internal alkynes bearing a hydroxy group, such as homopropargyl alcohol derivatives, successfully undergo thiolative carbonylation with carbon monoxide and an organic disulfide regio- and stereoselectively to afford the corresponding thio group bearing-lactones in good yields. In the Co-catalyzed reaction, the cobalt–alkyne complex from dicobalt octacarbonyl and internal alkyne acts as a key species, making it possible to attain thiolative lactonization of internal alkynes with a hydroxyl group. In the Pd-catalyzed reaction, the coordination of the hydroxy group to the palladium catalyst plays an important role for the thiolative lactonization.