Copper-Mediated Oxidative Coupling of Benzamides with
Maleimides via Directed C–H Cleavage
Wataru Miura
Koji Hirano
Masahiro Miura
10.1021/acs.orglett.5b01940.s001
https://acs.figshare.com/articles/journal_contribution/Copper_Mediated_Oxidative_Coupling_of_Benzamides_with_Maleimides_via_Directed_C_H_Cleavage/2139076
A Cu(OAc)<sub>2</sub>/Cy<sub>2</sub>NMe-mediated oxidative direct coupling of benzamides
with maleimides has been developed. The aromatic C–H alkenylation
with the aid of an 8-aminoquinoline-based bidentate directing group
is followed by an intramolecular aza-Michael-type addition to form
the isoindolone-incorporated spirosuccinimides, which are of potent
interest in medicinal chemistry.
2015-08-21 00:00:00
spirosuccinimide
maleimide
intramolecular
CleavageA
Oxidative
oxidative
Benzamide
bidentate
Maleimide
aid
benzamide
Cu
alkenylation