Copper-Mediated Oxidative Coupling of Benzamides with Maleimides via Directed C–H Cleavage Wataru Miura Koji Hirano Masahiro Miura 10.1021/acs.orglett.5b01940.s001 https://acs.figshare.com/articles/journal_contribution/Copper_Mediated_Oxidative_Coupling_of_Benzamides_with_Maleimides_via_Directed_C_H_Cleavage/2139076 A Cu­(OAc)<sub>2</sub>/Cy<sub>2</sub>NMe-mediated oxidative direct coupling of benzamides with maleimides has been developed. The aromatic C–H alkenylation with the aid of an 8-aminoquinoline-based bidentate directing group is followed by an intramolecular aza-Michael-type addition to form the isoindolone-incorporated spirosuccinimides, which are of potent interest in medicinal chemistry. 2015-08-21 00:00:00 spirosuccinimide maleimide intramolecular CleavageA Oxidative oxidative Benzamide bidentate Maleimide aid benzamide Cu alkenylation