Peptide Bioink: Self-Assembling Nanofibrous Scaffolds
for Three-Dimensional Organotypic Cultures
Yihua Loo
Anupama Lakshmanan
Ming Ni
Lai Ling Toh
Shi Wang
Charlotte A. E. Hauser
10.1021/acs.nanolett.5b02859.s002
https://acs.figshare.com/articles/media/Peptide_Bioink_Self_Assembling_Nanofibrous_Scaffolds_for_Three_Dimensional_Organotypic_Cultures/2122429
Printable scaffolds with adequate
mechanical strength and stiffness are sought after to ensure viability
of printed cells and tissues. We report the first peptide bioinks–lysine-containing
hexapeptides that self-assemble into stable, nanofibrous three-dimensional
hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible
scaffolds support the three-dimensional culture of human stem cells
and differentiation of primary cells into organotypic (gastrointestinal
and skin) structures for high-throughput screening, diagnosis, and
tissue engineering.
2015-10-14 00:00:00
40 kPa
biocompatible scaffolds support
tissue engineering
Peptide Bioink
stiffness