10.1021/acs.nanolett.5b02859.s002
Yihua Loo
Yihua
Loo
Anupama Lakshmanan
Anupama
Lakshmanan
Ming Ni
Ming
Ni
Lai Ling Toh
Lai Ling
Toh
Shi Wang
Shi
Wang
Charlotte A. E. Hauser
Charlotte
A. E. Hauser
Peptide Bioink: Self-Assembling Nanofibrous Scaffolds
for Three-Dimensional Organotypic Cultures
American Chemical Society
2015
40 kPa
biocompatible scaffolds support
tissue engineering
Peptide Bioink
stiffness
2015-10-14 00:00:00
Media
https://acs.figshare.com/articles/media/Peptide_Bioink_Self_Assembling_Nanofibrous_Scaffolds_for_Three_Dimensional_Organotypic_Cultures/2122429
Printable scaffolds with adequate
mechanical strength and stiffness are sought after to ensure viability
of printed cells and tissues. We report the first peptide bioinks–lysine-containing
hexapeptides that self-assemble into stable, nanofibrous three-dimensional
hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible
scaffolds support the three-dimensional culture of human stem cells
and differentiation of primary cells into organotypic (gastrointestinal
and skin) structures for high-throughput screening, diagnosis, and
tissue engineering.