Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation Pardeep Singh Erik Chorell K. Syam Krishnan Tomas Kindahl Jörgen Åden Pernilla Wittung-Stafshede Fredrik Almqvist 10.1021/acs.orglett.5b03190.s001 https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Multiring_Fused_2_Pyridones_via_a_Nitrene_Insertion_Reaction_Fluorescent_Modulators_of_Synuclein_Amyloid_Formation/2114281 An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted, intramolecular C–H amination reaction is reported. All the synthesized polyheterocycles were evaluated for their fluorescent properties and effect on α-synuclein amyloid formation. 2015-12-18 00:00:00 Fused Fluorescent Modulators intramolecular thiazolo Nitrene Insertion Reaction synuclein peptidomimetic polyheterocycles method synthesis Multiring Pyridone FormationAn Amyloid Synuclein formation amyloid amination Synthesi