Wei, Hongbo Li, Yun Xiao, Ke Cheng, Bin Wang, Huifei Hu, Lin Zhai, Hongbin Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields. electrocyclization;Polysubstituted Pyridines;cascade reaction;Staudinger reaction;Wittig reaction;strategy;access;aldehyde;azatriene;synthesis;phosphorus ylides;polysubstituted pyridines;StrategyAn;substrate;shift;yield;propargyl azide;Synthesi;reaction sequence 2015-12-18
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Polysubstituted_Pyridines_via_a_One_Pot_Metal_Free_Strategy/2097571
10.1021/acs.orglett.5b02903.s001