Regioselective Copper-Catalyzed
Dicarbonylation of
Imidazo[1,2‑<i>a</i>]pyridines with N,N-Disubstituted
Acetamide or Acetone: An Approach to 1,2-Diketones Using Molecular
Oxygen
Changcheng Wang
Sai Lei
Hua Cao
Shuxian Qiu
Jingyun Liu
Hao Deng
Caijuan Yan
10.1021/acs.joc.5b02417.s001
https://acs.figshare.com/articles/journal_contribution/Regioselective_Copper_Catalyzed_Dicarbonylation_of_Imidazo_1_2_i_a_i_pyridines_with_N_N_Disubstituted_Acetamide_or_Acetone_An_Approach_to_1_2_Diketones_Using_Molecular_Oxygen/2097511
A novel
copper-catalyzed regioselective double carbonylation of
imidazo[1,2-<i>a</i>]pyridines with N,N-disubstituted
acetamide or acetone using molecular oxygen has been described. It
has provided a new approach to synthesize 1,2-carbonyl imidazo[1,2-<i>a</i>]pyridines, which are important substrates and intermediates
in preparation of fine chemicals. The product shares a skeleton similar
to that of Zolpidem, one of the most prescribed drugs in the world. <sup>18</sup>O-labeling experiments unambiguously established that the
oxygen source of products originated from O<sub>2</sub> rather than
H<sub>2</sub>O.
2015-12-18 00:00:00
skeleton
OxygenA
carbonyl
O 2
Diketone
Zolpidem
Molecular
Approach
carbonylation
Dicarbonylation
Regioselective
regioselective
chemical
intermediate
acetone
Acetamide
Imidazo
oxygen source
approach
product shares
Acetone
experiment
acetamide
imidazo
world
2O
substrate
preparation