Regioselective Copper-Catalyzed Dicarbonylation of Imidazo[1,2‑<i>a</i>]pyridines with N,N-Disubstituted Acetamide or Acetone: An Approach to 1,2-Diketones Using Molecular Oxygen Changcheng Wang Sai Lei Hua Cao Shuxian Qiu Jingyun Liu Hao Deng Caijuan Yan 10.1021/acs.joc.5b02417.s001 https://acs.figshare.com/articles/journal_contribution/Regioselective_Copper_Catalyzed_Dicarbonylation_of_Imidazo_1_2_i_a_i_pyridines_with_N_N_Disubstituted_Acetamide_or_Acetone_An_Approach_to_1_2_Diketones_Using_Molecular_Oxygen/2097511 A novel copper-catalyzed regioselective double carbonylation of imidazo­[1,2-<i>a</i>]­pyridines with N,N-disubstituted acetamide or acetone using molecular oxygen has been described. It has provided a new approach to synthesize 1,2-carbonyl imidazo­[1,2-<i>a</i>]­pyridines, which are important substrates and intermediates in preparation of fine chemicals. The product shares a skeleton similar to that of Zolpidem, one of the most prescribed drugs in the world. <sup>18</sup>O-labeling experiments unambiguously established that the oxygen source of products originated from O<sub>2</sub> rather than H<sub>2</sub>O. 2015-12-18 00:00:00 skeleton OxygenA carbonyl O 2 Diketone Zolpidem Molecular Approach carbonylation Dicarbonylation Regioselective regioselective chemical intermediate acetone Acetamide Imidazo oxygen source approach product shares Acetone experiment acetamide imidazo world 2O substrate preparation