Brønsted Acid-Catalyzed
Reactions of Trifluoroborate
Salts with Benzhydryl Alcohols
Kayla
M. Fisher
Yuri Bolshan
10.1021/acs.joc.5b02273.s001
https://acs.figshare.com/articles/journal_contribution/Br_nsted_Acid_Catalyzed_Reactions_of_Trifluoroborate_Salts_with_Benzhydryl_Alcohols/2097415
Brønsted
acid-catalyzed carbon–carbon bond forming
methodology using potassium alkynyl- and alkenyltrifluoroborate salts
has been developed. Organotrifluoroborates react with benzhydryl alcohols
to afford a broad range of alkynes and alkenes in good to excellent
yields. This protocol features good atom economy because organotrifluoroborate
salts and alcohols react in a 1:1 ratio. Furthermore, a variety of
unprotected functional groups were tolerated under the developed conditions,
including amide, aldehyde, free hydroxyl, and carboxylic acid.
2015-12-18 00:00:00
atom economy
alkene
alkenyltrifluoroborate salts
yield
organotrifluoroborate salts
carboxylic acid
ratio
benzhydryl alcohols
AlcoholsBr
methodology
Br
ønsted
aldehyde
protocol features
Trifluoroborate Salts
Benzhydryl
potassium alkynyl
hydroxyl
amide
Organotrifluoroborate
variety
alkyne
bond