10.1021/acs.nanolett.5b04487.s001
Lu Liu
Lu
Liu
Meiqing Sun
Meiqing
Sun
Haijun Zhang
Haijun
Zhang
Qilin Yu
Qilin
Yu
Mingchun Li
Mingchun
Li
Yu Qi
Yu
Qi
Chengdong Zhang
Chengdong
Zhang
Guandao Gao
Guandao
Gao
Yingjin Yuan
Yingjin
Yuan
Huanhuan Zhai
Huanhuan
Zhai
Wei Chen
Wei
Chen
Pedro J. J. Alvarez
Pedro
J. J. Alvarez
Facet Energy and Reactivity versus Cytotoxicity: The
Surprising Behavior of CdS Nanorods
American Chemical Society
2016
faceted
nanorod
nanoparticle reactivity
CdS NanorodsResponsible development
unicellular microorganisms
endoplasmatic reticulum stress
Saccharomyces cerevisiae
Surprising Behavior
nanomaterial surface energy
cell viability
Facet Energy
cytotoxicity increases
2016-01-13 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Facet_Energy_and_Reactivity_versus_Cytotoxicity_The_Surprising_Behavior_of_CdS_Nanorods/2089630
Responsible development of nanotechnology
calls for improved understanding of how nanomaterial surface energy
and reactivity affect potential toxicity. Here, we challenge the paradigm
that cytotoxicity increases with nanoparticle reactivity. Higher-surface-energy
{001}-faceted CdS nanorods (CdS-H) were less toxic to <i>Saccharomyces
cerevisiae</i> than lower-energy ({101}-faceted) nanorods (CdS-L)
of similar morphology, aggregate size, and charge. CdS-H adsorbed
to the yeast’s cell wall to a greater extent than CdS-L, which
decreased endocytosis and cytotoxicity. Higher uptake of CdS-L decreased
cell viability and increased endoplasmatic reticulum stress despite
lower release of toxic Cd<sup>2+</sup> ions. Higher toxicity of CdS-L
was confirmed with five different unicellular microorganisms. Overall,
higher-energy nanocrystals may exhibit greater propensity to adsorb
to or react with biological protective barriers and/or background
constituents, which passivates their reactivity and reduces their
bioavailability and cytotoxicity.