10.1021/acsnano.5b06663.s001
Dongquan Shi
Dongquan
Shi
Xingquan Xu
Xingquan
Xu
Yanqi Ye
Yanqi
Ye
Kai Song
Kai
Song
Yixiang Cheng
Yixiang
Cheng
Jin Di
Jin
Di
Quanyin Hu
Quanyin
Hu
Jianxin Li
Jianxin
Li
Huangxian Ju
Huangxian
Ju
Qing Jiang
Qing
Jiang
Zhen Gu
Zhen
Gu
Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated
Nanoparticles for Cartilage Regeneration
American Chemical Society
2016
biomechanical tests
chondrogenesis effect
vivo studies
histological tests
SMSC
Cartilage RegenerationThe regeneration
cell transplantation
mesenchymal
KGN release system
BMSC
markers analysis
avascular tissue
regenerated tissues
healing response
cartilage
2016-01-26 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Photo_Cross_Linked_Scaffold_with_Kartogenin_Encapsulated_Nanoparticles_for_Cartilage_Regeneration/2083852
The regeneration of cartilage, an
aneural and avascular tissue,
is often compromised by its lack of innate abilities to mount a sufficient
healing response. Kartogenin (KGN), a small molecular compound, can
induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
The previous <i>in vitro</i> study showed that kartogenin
also had a chondrogenesis effect on synovium derived mesenchymal stem
cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive,
rapidly cross-linkable scaffold integrated with kartogenin-loaded
nanoparticles using an innovational one-step technology. <i>In
vivo</i> studies showed its potential role for cell homing, especially
for recruiting the host’s endogenous cells, including BMSCs
and SMSCs, without cell transplantation. Of note, the regenerated
tissues were close to the natural hyaline cartilage based on the histological
tests, specific markers analysis, and biomechanical tests. This innovative
KGN release system makes the chondrogenesis efficient and persistent.