10.1021/acsnano.5b06663.s001 Dongquan Shi Dongquan Shi Xingquan Xu Xingquan Xu Yanqi Ye Yanqi Ye Kai Song Kai Song Yixiang Cheng Yixiang Cheng Jin Di Jin Di Quanyin Hu Quanyin Hu Jianxin Li Jianxin Li Huangxian Ju Huangxian Ju Qing Jiang Qing Jiang Zhen Gu Zhen Gu Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration American Chemical Society 2016 biomechanical tests chondrogenesis effect vivo studies histological tests SMSC Cartilage RegenerationThe regeneration cell transplantation mesenchymal KGN release system BMSC markers analysis avascular tissue regenerated tissues healing response cartilage 2016-01-26 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Photo_Cross_Linked_Scaffold_with_Kartogenin_Encapsulated_Nanoparticles_for_Cartilage_Regeneration/2083852 The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. The previous <i>in vitro</i> study showed that kartogenin also had a chondrogenesis effect on synovium derived mesenchymal stem cells (SMSCs). Herein, we present the effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology. <i>In vivo</i> studies showed its potential role for cell homing, especially for recruiting the host’s endogenous cells, including BMSCs and SMSCs, without cell transplantation. Of note, the regenerated tissues were close to the natural hyaline cartilage based on the histological tests, specific markers analysis, and biomechanical tests. This innovative KGN release system makes the chondrogenesis efficient and persistent.