Organocatalytic Kinetic Resolution of Sulfoximines Shunxi Dong Marcus Frings Hanchao Cheng Jian Wen Duo Zhang Gerhard Raabe Carsten Bolm 10.1021/jacs.6b00143.s002 https://acs.figshare.com/articles/dataset/Organocatalytic_Kinetic_Resolution_of_Sulfoximines/2077960 An efficient kinetic resolution of sulfoximines with enals was realized using chiral <i>N</i>-heterocyclic carbene (NHC) catalysts. The stereoselective amidation proceeds without additional acyl transfer agent. Both enantiomers of the sulfoximines can be obtained with excellent ee values (up to 99% ee and −97% ee, respectively). Performing the catalysis on a gram scale allowed using the recovered sulfoximine (+)-<b>1j</b> in an asymmetric synthesis of FXa inhibitor <b>F</b>. 2016-02-04 00:00:00 sulfoximine gram scale NHC acyl transfer agent FXa inhibitor F Organocatalytic Kinetic Resolution stereoselective amidation proceeds ee values