10.1021/jacs.6b00143.s001 Shunxi Dong Shunxi Dong Marcus Frings Marcus Frings Hanchao Cheng Hanchao Cheng Jian Wen Jian Wen Duo Zhang Duo Zhang Gerhard Raabe Gerhard Raabe Carsten Bolm Carsten Bolm Organocatalytic Kinetic Resolution of Sulfoximines American Chemical Society 2016 sulfoximine gram scale NHC acyl transfer agent FXa inhibitor F Organocatalytic Kinetic Resolution stereoselective amidation proceeds ee values 2016-02-04 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Organocatalytic_Kinetic_Resolution_of_Sulfoximines/2077957 An efficient kinetic resolution of sulfoximines with enals was realized using chiral <i>N</i>-heterocyclic carbene (NHC) catalysts. The stereoselective amidation proceeds without additional acyl transfer agent. Both enantiomers of the sulfoximines can be obtained with excellent ee values (up to 99% ee and −97% ee, respectively). Performing the catalysis on a gram scale allowed using the recovered sulfoximine (+)-<b>1j</b> in an asymmetric synthesis of FXa inhibitor <b>F</b>.