10.1021/acs.bioconjchem.5b00396.s001
Quanjuan Zhang
Quanjuan
Zhang
Na Zhang
Na
Zhang
Yi-Tao Long
Yi-Tao
Long
Xuhong Qian
Xuhong
Qian
Youjun Yang
Youjun
Yang
Understanding the Selectivity of a Multichannel Fluorescent
Probe for Peroxynitrite Over Hypochlorite
American Chemical Society
2016
chemical community
hypochlorite
design probes
peroxynitrite anion
PN
reactive nitrogen species
nitric oxide
cell injuries
literature contributions
OONO
peroxynitrite probe
2016-02-10 15:47:21
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Understanding_the_Selectivity_of_a_Multichannel_Fluorescent_Probe_for_Peroxynitrite_Over_Hypochlorite/2077954
Peroxynitrite
is a prominent biological reactive nitrogen species
from radical combination of nitric oxide and superoxide and fundamentally
involved in broad spectrum physiological and pathological processes.
Though redox-inert itself, peroxynitrite anion (OONO<sup>–</sup>) attacks various biological electrophiles to generate an array of
potent 2-e<sup>–</sup> or 1-e<sup>–</sup> oxidants,
which result in cell injuries. Development of fluorescent probes for
peroxynitrite, free from interference from hypochlorite, has been
an active endeavor of the chemical community. We previously reported
a peroxynitrite probe (<b>PN600</b>), which could differentiate
hypochlorite from peroxynitrite through a multichannel signaling mechanism.
Herein, this intriguing selectivity was accounted for through a structure–reactivity
relationship study. Also, this work, together with rich literature
contributions, has allowed a qualitative guideline in the use of electron-rich
aromatic moieties to design probes against peroxynitrite and/or hypochlorite.
The viability of this guideline was further testified by development
of another list of peroxynitrite selective probes.