Palladium-Catalyzed
Synthesis of α‑Iminonitriles
from Aryl Halides via Isocyanide Double Insertion Reaction
Zhen-Bang Chen
Ying Zhang
Qing Yuan
Fang-Ling Zhang
Yong-Ming Zhu
Jing-Kang Shen
10.1021/acs.joc.5b02777.s001
https://acs.figshare.com/articles/journal_contribution/Palladium_Catalyzed_Synthesis_of_Iminonitriles_from_Aryl_Halides_via_Isocyanide_Double_Insertion_Reaction/2073685
An
efficient one-pot synthesis of α-iminonitriles from readily
available aryl halides via palladium-catalyzed double isocyanide insertion
and elimination has been developed, without using various hypertoxic
cyanides and excess oxidants. Furthermore, the utility of this reaction
was demonstrated by the rapid total synthesis of quinoxaline and the
reaction of functional groups exchanged with aryl halides.
2016-01-27 00:00:00
hypertoxic
Halide
insertion
utility
quinoxaline
oxidant
aryl halides
synthesis
Iminonitrile
elimination
Aryl
iminonitrile
isocyanide
Isocyanide Double Insertion ReactionAn
Synthesi