Copper(II)-Mediated <i>O</i>‑Arylation of Protected Serines and Threonines Mirna El Khatib Gary A. Molander 10.1021/ol5024689.s001 https://acs.figshare.com/articles/journal_contribution/Copper_II_Mediated_i_O_i_Arylation_of_Protected_Serines_and_Threonines/2040516 An effective protocol toward the <i>O</i>-arylation of β-hydroxy-α-amino acid substrates serine and threonine has been developed via Chan–Lam cross-coupling. This Cu­(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids. 2015-12-17 04:41:26 Protected Serines threonine derivatives Boc potassium organotrifluoroborates variety transformation serine Tr Fmoc boronic acids substrate ThreoninesAn Chan Cbz hydroxy Cu