Copper(II)-Mediated <i>O</i>‑Arylation
of Protected Serines and Threonines
Mirna El Khatib
Gary A. Molander
10.1021/ol5024689.s001
https://acs.figshare.com/articles/journal_contribution/Copper_II_Mediated_i_O_i_Arylation_of_Protected_Serines_and_Threonines/2040516
An
effective protocol toward the <i>O</i>-arylation of
β-hydroxy-α-amino acid substrates serine and threonine
has been developed via Chan–Lam cross-coupling. This Cu(II)-catalyzed
transformation involves benign open-flask conditions that are well-tolerated
with a variety of protected (Boc-, Cbz-, Tr-, and Fmoc-) serine and
threonine derivatives and various potassium organotrifluoroborates
and boronic acids.
2015-12-17 04:41:26
Protected Serines
threonine derivatives
Boc
potassium organotrifluoroborates
variety
transformation
serine
Tr
Fmoc
boronic acids
substrate
ThreoninesAn
Chan
Cbz
hydroxy
Cu