Walphos versus Biferrocene-Based Walphos Analogues in the Asymmetric Hydrogenation of Alkenes and Ketones Afrooz Zirakzadeh Manuela A. Groß Yaping Wang Kurt Mereiter Walter Weissensteiner 10.1021/om401074a.s002 https://acs.figshare.com/articles/dataset/Walphos_versus_Biferrocene_Based_Walphos_Analogues_in_the_Asymmetric_Hydrogenation_of_Alkenes_and_Ketones/2032272 Two representative Walphos analogues with an achiral 2,2″-biferrocenediyl backbone were synthesized. These diphosphine ligands were tested in the rhodium-catalyzed asymmetric hydrogenation of several alkenes and in the ruthenium-catalyzed hydrogenation of two ketones. The results were compared with those previously obtained on using biferrocene ligands with a <i>C</i><sub>2</sub>-symmetric 2,2″-biferrocenediyl backbone as well as with those obtained with Walphos ligands. The application of one newly synthesized ligand in the hydrogenation of 2-methylcinnamic acid gave (<i>R</i>)-2-methyl-3-phenylpropanoic acid with full conversion and with 92% ee. The same ligand was used to transform 2,4-pentanedione quantitatively and diastereoselectively into (<i>S</i>,<i>S</i>)-2,4-pentanediol with 98% ee. 2015-12-17 01:51:07 ee KetonesTwo representative Walphos analogues biferrocene ligands acid hydrogenation Walphos ligands Asymmetric Hydrogenation biferrocenediyl diphosphine ligands