10.1021/ol402225d.s001
Christopher D. Smith
Christopher D.
Smith
Michael F. Greaney
Michael F.
Greaney
Zinc Mediated Azide–Alkyne Ligation to 1,5- and 1,4,5-Substituted 1,2,3-Triazoles
American Chemical Society
2015
Azide
functionalized
Mediated
Ligation
azido
regioselective formation
strategy
TriazolesA
Substituted
method
triazole
substrate
room temperature
2015-12-16 23:35:14
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Zinc_Mediated_Azide_Alkyne_Ligation_to_1_5_and_1_4_5_Substituted_1_2_3_Triazoles/2025819
A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy.