10.1021/ol402225d.s001 Christopher D. Smith Christopher D. Smith Michael F. Greaney Michael F. Greaney Zinc Mediated Azide–Alkyne Ligation to 1,5- and 1,4,5-Substituted 1,2,3-Triazoles American Chemical Society 2015 Azide functionalized Mediated Ligation azido regioselective formation strategy TriazolesA Substituted method triazole substrate room temperature 2015-12-16 23:35:14 Journal contribution https://acs.figshare.com/articles/journal_contribution/Zinc_Mediated_Azide_Alkyne_Ligation_to_1_5_and_1_4_5_Substituted_1_2_3_Triazoles/2025819 A mild method for regioselective formation of 1,5-substituted 1,2,3-triazoles is described. The zinc-mediated reaction works at room temperature and is successful across a wide range of azido/alkynyl substrates. Additionally, the triazole 4-position can be further functionalized through the intermediate aryl-zinc to accommodate a diverse three-component coupling strategy.