A B<sub>2</sub>(OH)<sub>4</sub>‑Mediated Synthesis of 2‑Substituted Indazolone and Its Application in a DNA-Encoded Library Yapeng Bao Zongfa Deng Jing Feng Weiwei Zhu Jin Li Jinqiao Wan Guansai Liu 10.1021/acs.orglett.0c02032.s001 https://acs.figshare.com/articles/journal_contribution/A_B_sub_2_sub_OH_sub_4_sub_Mediated_Synthesis_of_2_Substituted_Indazolone_and_Its_Application_in_a_DNA-Encoded_Library/12751096 Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-substituted indazolones via B<sub>2</sub>(OH)<sub>4</sub>-mediated reductive <i>N</i>–<i>N</i> bond formation is developed. This strategy features mild conditions, no request for a metal catalyst, and a wide scope for both aliphatic and aromatic amines. Meanwhile, this method was further successfully applied on DNA to construct indazolone cores for a DNA-encoded library. This will enable the production of a very attractive indazolone-cored library from simple amines and scaffolds, which will provide considerable diversity. 2020-08-01 19:13:41 DNA-Encoded Library Indazolone cores B 2 Mediated indazolone-cored diversity amines scaffold strategy reductive Application 2- approach method Synthesi Substituted indazolone molecule component DNA-encoded formation catalyst scope aliphatic OH bond