10.1021/acs.orglett.0c02032.s001 Yapeng Bao Yapeng Bao Zongfa Deng Zongfa Deng Jing Feng Jing Feng Weiwei Zhu Weiwei Zhu Jin Li Jin Li Jinqiao Wan Jinqiao Wan Guansai Liu Guansai Liu A B<sub>2</sub>(OH)<sub>4</sub>‑Mediated Synthesis of 2‑Substituted Indazolone and Its Application in a DNA-Encoded Library American Chemical Society 2020 DNA-Encoded Library Indazolone cores B 2 Mediated indazolone-cored diversity amines scaffold strategy reductive Application 2- approach method Synthesi Substituted indazolone molecule component DNA-encoded formation catalyst scope aliphatic OH bond 2020-08-01 19:13:41 Journal contribution https://acs.figshare.com/articles/journal_contribution/A_B_sub_2_sub_OH_sub_4_sub_Mediated_Synthesis_of_2_Substituted_Indazolone_and_Its_Application_in_a_DNA-Encoded_Library/12751096 Indazolone cores are among the most common structural components in medicinal chemistry and can be found in many biologically active molecules. In this report, a mild and efficient approach to 2-substituted indazolones via B<sub>2</sub>(OH)<sub>4</sub>-mediated reductive <i>N</i>–<i>N</i> bond formation is developed. This strategy features mild conditions, no request for a metal catalyst, and a wide scope for both aliphatic and aromatic amines. Meanwhile, this method was further successfully applied on DNA to construct indazolone cores for a DNA-encoded library. This will enable the production of a very attractive indazolone-cored library from simple amines and scaffolds, which will provide considerable diversity.