%0 Journal Article
%A Qiu, Xiaodong
%A Li, Yangyang
%A Zhou, Li
%A Chen, Peishan
%A Li, Fan
%A Zhang, Yanan
%A Ling, Yong
%D 2020
%T Nickel(II)-Catalyzed Borylation of Alkenyl Methyl
Ethers via C–O Bond Cleavage
%U https://acs.figshare.com/articles/journal_contribution/Nickel_II_-Catalyzed_Borylation_of_Alkenyl_Methyl_Ethers_via_C_O_Bond_Cleavage/12749771
%R 10.1021/acs.orglett.0c02236.s001
%2 https://acs.figshare.com/ndownloader/files/24125867
%K B 2
%K Alkenyl Methyl Ethers
%K transformation exhibits
%K cross-coupling reaction
%K alkenyl methyl ethers
%K aryl ether
%K alkenyl ethers
%K thioether groups
%K alkenyl boronates
%K bond
%X A new protocol has
been developed for the borylation of conjugated
alkenyl methyl ethers using B2Pin2 via C–O
bond cleavage catalyzed by Ni(II). In this cross-coupling reaction,
both E/Z isomers of alkenyl ethers
are converted into (E)-alkenyl boronic esters with
good reactivity. This transformation exhibits high chemoselectivity
in the presence of competitive C–O bonds such as aryl ether,
ester, amide, and thioether groups, thus providing a new method for
the construction of various alkenyl boronates.
%I ACS Publications