%0 Journal Article %A Qiu, Xiaodong %A Li, Yangyang %A Zhou, Li %A Chen, Peishan %A Li, Fan %A Zhang, Yanan %A Ling, Yong %D 2020 %T Nickel(II)-Catalyzed Borylation of Alkenyl Methyl Ethers via C–O Bond Cleavage %U https://acs.figshare.com/articles/journal_contribution/Nickel_II_-Catalyzed_Borylation_of_Alkenyl_Methyl_Ethers_via_C_O_Bond_Cleavage/12749771 %R 10.1021/acs.orglett.0c02236.s001 %2 https://acs.figshare.com/ndownloader/files/24125867 %K B 2 %K Alkenyl Methyl Ethers %K transformation exhibits %K cross-coupling reaction %K alkenyl methyl ethers %K aryl ether %K alkenyl ethers %K thioether groups %K alkenyl boronates %K bond %X A new protocol has been developed for the borylation of conjugated alkenyl methyl ethers using B2Pin2 via C–O bond cleavage catalyzed by Ni­(II). In this cross-coupling reaction, both E/Z isomers of alkenyl ethers are converted into (E)-alkenyl boronic esters with good reactivity. This transformation exhibits high chemoselectivity in the presence of competitive C–O bonds such as aryl ether, ester, amide, and thioether groups, thus providing a new method for the construction of various alkenyl boronates. %I ACS Publications