10.1021/acs.orglett.0c02216.s001
Xiu-Fen Cheng
Xiu-Fen
Cheng
Fan Fei
Fan
Fei
Yan Li
Yan
Li
Yi-Ming Hou
Yi-Ming
Hou
Xin Zhou
Xin
Zhou
Xi-Sheng Wang
Xi-Sheng
Wang
Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective
Amination of C(sp<sup>2</sup>)–H Bonds
American Chemical Society
2020
Enantioselective
acetate
Pd
enantioselective
ligand
hexafluoroacetylacetate
methylhydroxamic acid
reactivity enhancement
identification
realization
role
Palladium
transformation
medium
Ligand-Accelerated
Amination
counteranion
amination
Bond
stereocontrol
MPAHA
control enantioselectivity
aryl
α-
bond
2020-07-31 22:29:35
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Ligand-Accelerated_Palladium_II_-Catalyzed_Enantioselective_Amination_of_C_sp_sup_2_sup_H_Bonds/12749768
The first example of the Pd(II)-catalyzed
enantioselective amination
of aryl C–H bonds is reported. The key to the successful realization
of this asymmetric catalytic transformation was the identification
of mono-<i>N</i>-protected α-amino-<i>O</i>-methylhydroxamic acid (MPAHA) ligands, which promote reactivity
under mild conditions and control enantioselectivity. The counteranions
in the solvent medium, hexafluoroacetylacetate and acetate, were also
found to play key roles in stereocontrol and reactivity enhancement.