10.1021/acs.orglett.0c02216.s001 Xiu-Fen Cheng Xiu-Fen Cheng Fan Fei Fan Fei Yan Li Yan Li Yi-Ming Hou Yi-Ming Hou Xin Zhou Xin Zhou Xi-Sheng Wang Xi-Sheng Wang Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp<sup>2</sup>)–H Bonds American Chemical Society 2020 Enantioselective acetate Pd enantioselective ligand hexafluoroacetylacetate methylhydroxamic acid reactivity enhancement identification realization role Palladium transformation medium Ligand-Accelerated Amination counteranion amination Bond stereocontrol MPAHA control enantioselectivity aryl α- bond 2020-07-31 22:29:35 Journal contribution https://acs.figshare.com/articles/journal_contribution/Ligand-Accelerated_Palladium_II_-Catalyzed_Enantioselective_Amination_of_C_sp_sup_2_sup_H_Bonds/12749768 The first example of the Pd­(II)-catalyzed enantioselective amination of aryl C–H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-<i>N</i>-protected α-amino-<i>O</i>-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.