Corpas, Javier Mauleón, Pablo Gómez Arrayás, Ramón Carretero, Juan C. <i>anti</i>-Hydroarylation of Activated Internal Alkynes: Merging Pd and Energy Transfer Catalysis A general catalytic <i>anti</i>-hydroarylation of electron-deficient internal alkynes compatible with both electron-poor and electron-rich aryl reagents is reported. This selectivity is achieved through a sequential <i>syn</i>-carbopalladation of the alkyne by an Ar–Pd species, followed by a tandem, Ir-photocatalyzed, counter-thermodynamic <i>E</i> → <i>Z</i> isomerization. The use of <i>ortho</i>-substituted boronic acids enables direct access to pharmaceutically relevant heterocyclic cores via a cascade process. Mechanistic insight into the involvement of Ar–Pd versus Pd–H as an active species is provided. Hydroarylation;sequential syn;ortho;selectivity;heterocyclic cores;Mechanistic insight;species;hydroarylation;electron-rich aryl reagents;access;electron-poor;Merging Pd;counter-thermodynamic;cascade process;Activated Internal Alkynes;pharmaceutically;tandem;involvement;boronic acids;Ir-photocatalyzed;Energy Transfer Catalysis;alkyne;carbopalladation;electron-deficient;Ar;isomerization 2020-07-31
    https://acs.figshare.com/articles/journal_contribution/_i_anti_i_-Hydroarylation_of_Activated_Internal_Alkynes_Merging_Pd_and_Energy_Transfer_Catalysis/12749757
10.1021/acs.orglett.0c02281.s001