Fan, Liangxin Hao, Jiamao Yu, Jingxun Ma, Xiaojun Liu, Jingjing Luan, Xinjun Hydroxylamines As Bifunctional Single-Nitrogen Sources for the Rapid Assembly of Diverse Tricyclic Indole Scaffolds Conventional approaches on using hydroxylamine derivatives as single nitrogen sources, for the construction of <i>n</i>-membered (<i>n</i> > 3) N-heterocycles, rely upon two chemical operations by involving sequential nucleophilic and electrophilic C–N bond formations. Here, we report a highly efficient cascade of alkyne insertion/C–H activation/amination for the rapid preparation of a myriad of tricyclic indoles, in a single-step transformation, by using bifunctional secondary hydroxylamines. It is noteworthy that judicious selection of applicable amino agents, for enabling the prior oxidative addition of aryl iodide to initial Pd(0) species and subsequent two C–N bonds formation, was the key to the success of this reaction. Control experiments indicated that a five-membered palladacyclic intermediate played a crucial role in promoting the final aminative ring closure. insertion;sequential nucleophilic;Rapid Assembly;alkyne;Diverse Tricyclic Indole Scaffolds;Bifunctional Single-Nitrogen Sources;N-heterocycle;hydroxylamine derivatives;aryl iodide;electrophilic;species;control experiments;role;aminative ring closure;five-membered palladacyclic;approach;transformation;chemical operations;activation;construction;formation;tricyclic indoles;bifunctional;nitrogen sources;Hydroxylamine;preparation;cascade;oxidative addition;agent;Pd;bond 2020-03-26
    https://acs.figshare.com/articles/dataset/Hydroxylamines_As_Bifunctional_Single-Nitrogen_Sources_for_the_Rapid_Assembly_of_Diverse_Tricyclic_Indole_Scaffolds/12037485
10.1021/jacs.0c00403.s008