Artepillin C, a Key Component of Brazilian Propolis,
Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through
a Creatine-Metabolism-Related Thermogenic Pathway
Sho Nishikawa
Takuma Hydo
Hiroki Aoyama
Ryo Miyata
Shigenori Kumazawa
Takanori Tsuda
10.1021/acs.jafc.9b07080.s001
https://acs.figshare.com/articles/journal_contribution/Artepillin_C_a_Key_Component_of_Brazilian_Propolis_Induces_Thermogenesis_in_Inguinal_White_Adipose_Tissue_of_Mice_through_a_Creatine-Metabolism-Related_Thermogenic_Pathway/11652327
Induction
of beige adipocytes in white adipose tissue (WAT) is
a potential therapeutic target for the treatment of obesity because
beige adipocytes release excess energy via uncoupling-protein-1-associated
thermogenesis. In this study, we investigated how artepillin C (ArtC)
promotes thermogenesis <i>in vivo</i>. We demonstrated that
28 day administration of ArtC (10 mg/kg of body weight) to mice significantly
induced thermogenesis in beige adipocytes in inguinal WAT (iWAT) and
suppressed reductions in core body temperature induced by cold exposure
at 4 °C. Moreover, ArtC-induced thermogenesis in iWAT was significantly
inhibited by treatment with a creatine metabolism inhibitor, and ArtC
significantly upregulated the expression of creatine-metabolism-related
enzymes in the thermogenic pathway. These results indicate that ArtC
induces thermogenesis in beige adipocytes in iWAT, and the observed
ArtC-induced thermogenesis is associated with the creatine-metabolism-related
thermogenic pathway, which is characteristically observed in beige
adipocytes.
2020-01-18 20:13:43
creatine-metabolism-related thermogenic pathway
Inguinal White Adipose Tissue
WAT
core body temperature
creatine metabolism inhibitor
uncoupling-protein -1-associated thermogenesis
iWAT
ArtC-induced thermogenesis
Creatine-Metabolism-Related Thermogenic Pathway Induction
adipocyte
28 day administration