Elling, Benjamin R. Su, Jessica K. Xia, Yan Degradable Polyacetals/Ketals from Alternating Ring-Opening Metathesis Polymerization We report the synthesis of degradable polyacetals and polyketals with controlled molecular weights and low dispersities using alternating ring-opening metathesis polymerization (AROMP) of 1,1-disubstituted cyclopropenes and dioxepins. Under optimized conditions, high degrees of alternation and controlled polymerization were achieved between nonpropagating cyclopropenes and low-strain dioxepins. The high degrees of alternation allowed the resulting polymers to fully degrade into small molecules under acidic conditions at variable rates depending on the acetal/ketal structures. This synthetic strategy illustrates the use of AROMP to incorporate functionalities into both the polymer backbone as well as the side chains. Ring-Opening Metathesis Polymerization;alternation;disubstituted;polyketal;strategy;acidic conditions;AROMP;synthesis;ring-opening metathesis polymerization;low-strain dioxepins;molecule;functionalitie;polymer backbone;dispersitie;side chains;Polyacetal;Degradable;nonpropagating cyclopropenes;degradable polyacetals;optimized conditions 2020-01-17
    https://acs.figshare.com/articles/journal_contribution/Degradable_Polyacetals_Ketals_from_Alternating_Ring-Opening_Metathesis_Polymerization/11637495
10.1021/acsmacrolett.9b00936.s001