Gordon, Eric M. Duncton, Matthew A. J. Wang, Brian J. Qi, Longwu Fan, Dazhong Li, Xianfeng Ni, Zhi-Jie Ding, Pingyu Grygorash, Ruslan Low, Eddy Yu, Guijun Sun, Jiawei Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2 Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is less than 1%. Herein we describe the design and synthesis of potential oral prodrugs of aztreonam. FDA;Gram-negative bacteria;Part 2 Aztreonam;monocyclic beta-lactam antibiotic;aztreonam;Novel Prodrugs;Sulfate Containing Drugs;Antibiotic Aztreonam 2020-01-10
    https://acs.figshare.com/articles/journal_contribution/Toward_Orally_Absorbed_Prodrugs_of_the_Antibiotic_Aztreonam_Design_of_Novel_Prodrugs_of_Sulfate_Containing_Drugs_Part_2/11568711
10.1021/acsmedchemlett.9b00534.s001