Iron-Catalyzed Transfer Hydrogenation in Aged <i>N</i>‑Methyl-2-pyrrolidone: Reductive Ring-Opening of 3,5-Disubstituted Isoxazoles and Isoxazolines Xiaochen Liu Dongsub Hong Netanel G. Sapir Wen Yang William H. Hersh Pak-Hing Leung Dingqiao Yang Yu Chen 10.1021/acs.joc.9b02733.s001 https://acs.figshare.com/articles/dataset/Iron-Catalyzed_Transfer_Hydrogenation_in_Aged_i_N_i_Methyl-2-pyrrolidone_Reductive_Ring-Opening_of_3_5-Disubstituted_Isoxazoles_and_Isoxazolines/11353436 3,5-Disubstituted isoxazoles and isoxazolines undergo an iron-catalyzed reductive ring-opening in aged <i>N</i>-methyl-2-pyrrolidone (NMP). 5-Hydroxy-<i>N</i>-methyl-2-pyrrolidone generated <i>in situ</i> via a simple activation of commercial NMP acts as the hydrogen donor in the iron-catalyzed transfer hydrogenation reaction. It is the first example employing a combination of an iron catalyst and 5-hydroxy-<i>N</i>-methyl-2-pyrrolidone as reducing agents in a transfer hydrogenation reaction. The protocol is highly efficient for the synthesis of β-enaminones and 1,3-diketones, providing a versatile route for the preparation of these 1,3-difunctional compounds bearing diversified substitution patterns. 2019-12-11 13:12:32 Iron-Catalyzed Transfer Hydrogenation iron-catalyzed transfer hydrogenation reaction Disubstituted transfer hydrogenation reaction 5- methyl -2-pyrrolidone NMP iron-catalyzed reductive ring-opening