Iron-Catalyzed Transfer
Hydrogenation in Aged <i>N</i>‑Methyl-2-pyrrolidone: Reductive Ring-Opening of 3,5-Disubstituted Isoxazoles and Isoxazolines
Xiaochen Liu
Dongsub Hong
Netanel G. Sapir
Wen Yang
William H. Hersh
Pak-Hing Leung
Dingqiao Yang
Yu Chen
10.1021/acs.joc.9b02733.s001
https://acs.figshare.com/articles/dataset/Iron-Catalyzed_Transfer_Hydrogenation_in_Aged_i_N_i_Methyl-2-pyrrolidone_Reductive_Ring-Opening_of_3_5-Disubstituted_Isoxazoles_and_Isoxazolines/11353436
3,5-Disubstituted isoxazoles and isoxazolines undergo
an iron-catalyzed
reductive ring-opening in aged <i>N</i>-methyl-2-pyrrolidone
(NMP). 5-Hydroxy-<i>N</i>-methyl-2-pyrrolidone generated <i>in situ</i> via a simple activation of commercial NMP acts as
the hydrogen donor in the iron-catalyzed transfer hydrogenation reaction.
It is the first example employing a combination of an iron catalyst
and 5-hydroxy-<i>N</i>-methyl-2-pyrrolidone as reducing
agents in a transfer hydrogenation reaction. The protocol is highly
efficient for the synthesis of β-enaminones and 1,3-diketones,
providing a versatile route for the preparation of these 1,3-difunctional
compounds bearing diversified substitution patterns.
2019-12-11 13:12:32
Iron-Catalyzed Transfer Hydrogenation
iron-catalyzed transfer hydrogenation reaction
Disubstituted
transfer hydrogenation reaction
5-
methyl -2-pyrrolidone
NMP
iron-catalyzed reductive ring-opening