Nallasivam, Jothi Lakshmi Chakraborty, Tushar Kanti Titanocene(III)-Mediated 5‑exo-trig Radical Cyclization: En Route to Spirooxindole-Based Tetrahydrofuran and Bicyclic Lactone The isatin core system is of immense importance due to the highly reactive prochiral C-3 position, which paves an easy way to construct large arrays of spirooxindole heterocyclic motifs. Herein, we depict an isatin-derived and 3,3′-disubstituted oxindole-appended epoxy-acrylate undergoing Cp<sub>2</sub>Ti­(III)­Cl-mediated reductive oxirane-ring opening with concomitant intramolecular 5-exo-trig radical cyclization leading to tetrahydrofuran-based oxa-spirooxindole systems. The fused spirooxindole structural feature is embedded in many natural products and tends to exhibit a wide spectrum of biological activities. The presence of more than one quaternary center and the availability of multiple functional groups like hydroxyl, ester, or lactone in the resultant products expand the scope of synthetic applications of the newly acquired oxa-spirooxindole molecules. exhibit;oxirane-ring;Spirooxindole-Based Tetrahydrofuran;cyclization;Cyclization;Ti;isatin core system;array;availability;Bicyclic Lactone;epoxy-acrylate;En Route;Titanocene;presence;tetrahydrofuran-based oxa-spirooxindole systems;ester;scope;lactone;quaternary center;reductive;opening;importance;spectrum;intramolecular 5- exo-trig;reactive prochiral C -3 position;application;oxa-spirooxindole molecules;oxindole-appended;Radical;Herein;disubstituted;isatin-derived;Cp;spirooxindole heterocyclic motifs;hydroxyl 2019-12-11
    https://acs.figshare.com/articles/dataset/Titanocene_III_-Mediated_5_exo-trig_Radical_Cyclization_En_Route_to_Spirooxindole-Based_Tetrahydrofuran_and_Bicyclic_Lactone/11353409
10.1021/acs.joc.9b02608.s003