Development
of Sodium Polyacrylate-Based High-Performance
Submucosal Injection Material with Pseudoplastic Fluid Characteristics
Ryohei Hirose
Naohisa Yoshida
Yuji Naito
Takuma Yoshida
Risa Bandou
Tomo Daidoji
Ken Inoue
Osamu Dohi
Hideyuki Konishi
Takaaki Nakaya
Yoshito Itoh
10.1021/acsbiomaterials.9b01373.s001
https://acs.figshare.com/articles/journal_contribution/Development_of_Sodium_Polyacrylate-Based_High-Performance_Submucosal_Injection_Material_with_Pseudoplastic_Fluid_Characteristics/11212430
The development of high-performance submucosal injection
materials
(SIMs) has significantly contributed to the advancement of rapid and
safe endoscopic submucosal dissection (ESD). A previous study authored
by us described that pseudoplastic fluid was more suitable for high-performance
SIMs than Newtonian fluid. Herein, a novel high-performance SIM is
developed, which is primarily composed of sodium polyacrylate (SPA)
and exhibits pseudoplastic fluid characteristics. As a representative
of current high-performance SIMs with Newtonian fluid characteristics,
0.4% sodium hyaluronate (HA) was selected as the target for comparison.
Further, viscoelasticity, submucosal elevation height (SEH), and injection
pressure (IP) of HA and SPA were evaluated. The results obtained by
ESD were compared using HA or SPA in an ex vivo model. According to
the measured viscoelasticity, the concentration of SPA was adjusted
to 0.07%; this was aimed at obtaining the IP of SPA, which is equal
to that of 0.4% HA. Moreover, no significant difference was observed
between the IP values (31.6 ± 1.7 vs 31.4 ± 3.1 psi). SEHs
of 0.07% SPA were higher than those of 0.4% HA at all postinjection
times (<i>P</i> < 0.001). The duration of the ESD procedure
using 0.07% SPA was significantly shorter than that obtained using
0.4% HA (16.6 ± 3.7 vs 22.2 ± 2.9 min, <i>P</i> = 0.0276); further, the total volume of the injected 0.07% SPA was
significantly less than that of 0.4% HA (9.0 ± 3.1 vs 15.7 ±
3.9 mL, <i>P</i> = 0.0165). Based on rheological analysis,
a high-performance SIM (0.07% SPA) with pseudoplastic fluid characteristics
was theoretically developed. It was observed that the SIM performance
of 0.07% SPA was higher than that of 0.4% HA.
2019-11-26 15:38:18
Pseudoplastic Fluid Characteristics
SPA
endoscopic submucosal dissection
injection pressure
exhibits pseudoplastic fluid characteristics
HA
submucosal injection materials
Newtonian fluid
pseudoplastic fluid
Sodium Polyacrylate-Based High-Performance Submucosal Injection Material
vivo model
SEH
submucosal elevation height
SIM performance
postinjection times
ESD procedure
IP
rheological analysis
sodium polyacrylate
Newtonian fluid characteristics
pseudoplastic fluid characteristics