Iron–Copper
Bimetallic Nanocomposite Reinforced Dressing Materials for Infection
Control and Healing of Diabetic Wound
Madhumita Das
Upashi Goswami
Raghuram Kandimalla
Sanjeeb Kalita
Siddhartha Sankar Ghosh
Arun Chattopadhyay
10.1021/acsabm.9b00870.s001
https://acs.figshare.com/articles/journal_contribution/Iron_Copper_Bimetallic_Nanocomposite_Reinforced_Dressing_Materials_for_Infection_Control_and_Healing_of_Diabetic_Wound/10354445
A multifunctional nanomaterial based wound healing matrix
was fabricated by modified co-precipitation and chemical reduction
method. The matrix was comprised of either a bimetallic Fe–Cu
nanocomposite powder or a wound bed made up of absorbent cotton swab
impregnated with bimetallic Fe–Cu nanocomposite. The detailed
analytical studies of both dressing materials (powder and cotton bed)
were carried out with transmission electron microscopy, X-ray diffraction,
field emission scanning electron microscopy, energy-dispersive X-ray,
and bright field microscopy. Both the nanocomposite powder and the
nanocomposite impregnated cotton swab exhibited antimicrobial activity
against Gram positive and Gram negative bacteria, including multidrug-resistant
bacteria (such as methicillin-resistant <i>Staphylococcus aureus</i>) as well as against fungus isolated from different human biological
samples (pus/tissue culture/urine). For real time applications, the
in vivo wound healing ability of both dressing materials was also
carried out in Wistar albino rats with infected diabetic wounds. These
biocompatible and biodegradable dressing materials with broad-spectrum
antimicrobial properties have exhibited more than 20 mm in diameter
zone of microbial growth inhibition against several types of microbes.
Remarkably, they have also been found to assist in healing of infected
diabetic wounds and show a prospect in the management of other infectious
wounds.
2019-11-19 17:05:02
methicillin-resistant Staphylococcus aureus
nanocomposite impregnated cotton
Wistar albino rats
field emission scanning electron microscopy
wound healing matrix
broad-spectrum antimicrobial properties
transmission electron microscopy
chemical reduction method
vivo wound healing ability
dressing materials